PIAS1

Across TCGA cell cohorts, PIAS1 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIAS1-associated genes across cancer lineages are CLEC10A, SPATA48, and GALR1. Each is linked with PIAS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIAS1-to-partner and partner-to-PIAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC10A grouped by PIAS1-low versus PIAS1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIAS1→partner) and Y-score (partner→PIAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CLEC10A →	+0.074	+4.472	.008	.004	3	1
CNS	SPATA48 →	+0.027	+5.357	<.001	.001	3	1
CNS	GALR1 →	+0.247	+4.832	<.001	.002	3	1
CNS	C10orf71 →	+0.006	+5.566	.004	<.001	3	1
CNS	OR5M8 →	+0.017	+4.754	<.001	.005	3	1
CNS	SPATA31A6 →	+0.122	+4.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

CLEC10A by PIAS1 expression — CNS

Explore this box plot interactively →