PIAS1

Across TCGA pan-cancer cohorts, PIAS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PIAS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PIAS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PIAS1 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and LIHC are the cancer types where PIAS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIAS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.117	<.001	9	view →
LUAD	Female	III,IV	−1.092	<.001	7	view →
LIHC	All	II,III,IV	+0.738	<.001	7	view →
CHOL	All	All	+1.596	<.001	5	view →
LUSC	All	All	−0.497	<.001	5	view →
UCEC	All	All	−0.971	<.001	4	view →
BRCA	Female	All	−0.163	.040	2	view →
ESCA	All	II,III,IV	−0.115	.044	2	view →
STAD	All	IV	+0.853	.028	1	view →
BLCA	Male	IV	−0.677	.039	1	view →
HNSC	Female	III,IV	+0.585	.028	1	view →
COAD	All	All	−0.185	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PIAS1–THCA

Open the THCA breakdown →