PI4KA

Across TCGA cell cohorts, PI4KA mutation is significantly associated with the RNA expression of many other genes, with 1,664 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PI4KA-associated genes across cancer lineages are INSL5, MUC5AC, and C7orf33. Each is linked with PI4KA in more than 2 cancer types. Because this analysis shows association rather than direction, both PI4KA-to-partner and partner-to-PI4KA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INSL5 grouped by PI4KA-low versus PI4KA-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PI4KA→partner) and Y-score (partner→PI4KA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	INSL5 →	+0.056	+4.222	<.001	.002	3	3
BLOOD_Myeloma	MUC5AC →	+0.018	+4.807	<.001	.006	3	2
PANCREAS	C7orf33 →	+0.020	+4.029	<.001	.007	3	2
PANCREAS	OPALIN →	+0.008	+3.491	.009	.008	3	2
LARGE_INTESTINE	FAM149A →	+1.307	+3.404	<.001	<.001	3	2
LARGE_INTESTINE	MRPL2 →	+0.426	+3.087	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,664 associations by consensus.

INSL5 by PI4KA expression — PANCREAS

Explore this box plot interactively →