PI4KA

Across TCGA pan-cancer cohorts, PI4KA RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PI4KA’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PI4KA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PI4KA is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

HNSC, LIHC, and KIRC are the cancer types where PI4KA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PI4KA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.719	<.001	10	view →
LIHC	Female	All	+0.968	<.001	8	view →
KIRC	Male	II,III,IV	−0.487	<.001	6	view →
CHOL	All	All	+1.364	<.001	4	view →
BRCA	All	II,III,IV	+0.227	.009	4	view →
COAD	All	II,III,IV	−0.225	.015	3	view →
KIRP	Male	All	−0.591	.005	2	view →
THCA	All	II,III,IV	−0.284	.038	2	view →
BLCA	Male	IV	−0.639	.018	1	view →
STAD	Male	II,III,IV	+0.592	.042	1	view →
READ	All	All	−0.447	.018	1	view →
LUAD	All	All	−0.217	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PI4KA–HNSC

Open the HNSC breakdown →