PHOX2B

Across TCGA patient cohorts, PHOX2B RNA expression is significantly associated with the go_rna of many other GO terms, with 6,617 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PHOX2B-associated GO terms across cancer lineages are Negative regulation of growth, Response to reactive oxygen species, and Response to hydrogen peroxide. Each is linked with PHOX2B in more than 13 cancer types. Because this analysis shows association rather than direction, both PHOX2B-to-partner and partner-to-PHOX2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of growth grouped by PHOX2B-low versus PHOX2B-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHOX2B→partner) and Y-score (partner→PHOX2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Negative regulation of growth →	+0.051	+0.215	<.001	<.001	3	14
STAD	Response to reactive oxygen species →	+0.056	+0.148	<.001	<.001	3	11
STAD	Response to hydrogen peroxide →	+0.087	+0.161	<.001	<.001	3	11
STAD	Roof of mouth development →	+0.047	+0.157	<.001	<.001	3	11
STAD	Cellular response to radiation →	+0.063	+0.110	<.001	.002	2	11
STAD	Positive regulation of DNA-templated transcription, elongation →	+0.082	+0.159	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,617 associations by consensus.

Negative regulation of growth by PHOX2B expression — STAD

Explore this box plot interactively →