PHOX2B

Across TCGA pan-cancer cohorts, PHOX2B RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of PHOX2B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PHOX2B RNA is repressed in tumor relative to normal tissue. In most cancer types PHOX2B is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, READ, and STAD are the cancer types where PHOX2B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PHOX2B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−1.457	<.001	12	view →
READ	Female	All	−1.914	<.001	5	view →
STAD	All	All	−0.586	.002	5	view →
KIRC	Male	All	−0.004	.001	5	view →
LUAD	All	All	+0.106	.035	2	view →
UCEC	All	IV	+0.070	.019	2	view →
BLCA	All	All	−0.028	.033	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

PHOX2B–COAD

Open the COAD breakdown →