PHOX2B

Across TCGA pan-cancer cohorts, PHOX2B RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PHOX2B data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PHOX2B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PHOX2B expression acts as an unfavorable survival marker, although some lineages such as BLCA and SKCM show a favorable association.

KIRC, OV, and THYM are the cancer types where PHOX2B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.519	0.664	<.001	95	view →
OV	OS	Tertile	All	0.252	0.339	.008	72	view →
THYM	OS	Tertile	III,IV	0.103	0.944	<.001	54	view →
LUSC	DFS	Tertile	All	0.241	0.406	.013	51	view →
UCEC	OS	Quartile	All	0.877	0.935	.001	48	view →
SCLC	DFS	Tertile	All	0.358	0.921	<.001	42	view →
HNSC	DFS	Tertile	II,III,IV	0.487	0.642	.012	39	view →
ACC	OS	Tertile	All	0.154	0.726	<.001	36	view →
LGG	OS	Quartile	All	0.836	0.909	.003	36	view →
LIHC	DFS	Tertile	II,III,IV	0.066	0.417	<.001	33	view →
DLBC	OS	Tertile	II,III,IV	0.279	1.000	.003	30	view →
ESCA	DFS	Median	All	0.297	0.460	.003	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PHOX2B–KIRC (DFS)

Open the KIRC breakdown →