PHOX2B

Across TCGA patient cohorts, PHOX2B mutation is significantly associated with the RNA expression of many other genes, with 2,389 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHOX2B-associated genes across cancer lineages are RN7SKP263, MIR7845, and PSMA6. Each is linked with PHOX2B in more than 1 cancer types. Because this analysis shows association rather than direction, both PHOX2B-to-partner and partner-to-PHOX2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP263 grouped by PHOX2B-low versus PHOX2B-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHOX2B→partner) and Y-score (partner→PHOX2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SKP263 →	+0.140	+5.351	<.001	.002	3	2
SKCM	MIR7845 →	+0.344	+3.086	<.001	<.001	3	2
SKCM	PSMA6 →	+0.442	+2.839	.004	.001	3	2
SKCM	MTRF1L →	+0.448	+2.516	.008	.009	3	2
UCEC	FKBP3 →	+0.578	+3.595	.001	.001	3	2
UCEC	GNPNAT1 →	+0.534	+2.447	.006	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,389 associations by consensus.

RN7SKP263 by PHOX2B expression — HNSC

Explore this box plot interactively →