PHOX2B

Across TCGA cell cohorts, PHOX2B RNA expression is significantly associated with the go_rna of many other GO terms, with 776 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PHOX2B-associated GO terms across cancer lineages are Regulation of Golgi inheritance, Negative regulation of myoblast fusion, and Regulation of post-translational protein modification. Each is linked with PHOX2B in more than 4 cancer types. Because this analysis shows association rather than direction, both PHOX2B-to-partner and partner-to-PHOX2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of Golgi inheritance grouped by PHOX2B-low versus PHOX2B-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHOX2B→partner) and Y-score (partner→PHOX2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of Golgi inheritance →	+0.083	+0.021	.001	.005	3	4
BLOOD_Leukemia	Negative regulation of myoblast fusion →	+0.054	+0.007	<.001	.007	3	4
UPPER_AERODIGESTIVE_TRACT	Regulation of post-translational protein modification →	+0.047	+0.039	<.001	.006	2	5
BLOOD_Leukemia	Regulation of cell cycle G1/S phase transition →	+0.063	+0.015	<.001	<.001	3	4
BLOOD_Leukemia	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.044	+0.007	<.001	.001	3	4
BLOOD_Leukemia	Golgi vesicle transport →	+0.025	+0.009	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 776 associations by consensus.

Regulation of Golgi inheritance by PHOX2B expression — SKIN

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