PHOX2B

Across TCGA cell cohorts, PHOX2B mutation is significantly associated with the RNA expression of many other genes, with 86 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHOX2B-associated genes across cancer lineages are MYBPC3, ADIPOQ, and HYAL4. Each is linked with PHOX2B in more than 1 cancer types. Because this analysis shows association rather than direction, both PHOX2B-to-partner and partner-to-PHOX2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYBPC3 grouped by PHOX2B-low versus PHOX2B-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHOX2B→partner) and Y-score (partner→PHOX2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MYBPC3 →	+0.016	+4.273	<.001	.006	3	2
PANCREAS	ADIPOQ →	+0.006	+5.000	<.001	.006	3	1
SOFT_TISSUE	HYAL4 →	+0.785	+3.295	<.001	.006	3	1
SOFT_TISSUE	SPATA19 →	+0.015	+3.977	<.001	.007	3	1
OVARY	OR2H1 →	+0.027	+4.029	<.001	.009	3	1
CNS	DBX1 →	+0.620	+4.315	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

MYBPC3 by PHOX2B expression — SKIN

Explore this box plot interactively →