PHIP

Across TCGA cell cohorts, PHIP mutation is significantly associated with the RNA expression of many other genes, with 199 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHIP-associated genes across cancer lineages are CRYBB1, MS4A14, and TIFAB. Each is linked with PHIP in more than 1 cancer types. Because this analysis shows association rather than direction, both PHIP-to-partner and partner-to-PHIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYBB1 grouped by PHIP-low versus PHIP-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHIP→partner) and Y-score (partner→PHIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CRYBB1 →	+0.032	+4.736	<.001	.009	3	2
OESOPHAGUS	MS4A14 →	+0.053	+4.906	<.001	.006	3	2
CNS	TIFAB →	+0.005	+3.244	<.001	.005	3	2
LARGE_INTESTINE	F13B →	+0.044	+2.827	.009	.002	3	2
LARGE_INTESTINE	C15orf61 →	+0.392	+3.169	.003	.009	3	2
PANCREAS	DHRS7C →	+0.075	+5.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 199 associations by consensus.

CRYBB1 by PHIP expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →