PHIP

Across TCGA pan-cancer cohorts, PHIP RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PHIP data layer compared with 9 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher PHIP RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PHIP expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

LIHC, HNSC, and KICH are the cancer types where PHIP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Quartile	All	0.423	0.641	<.001	76	view →
HNSC	DFS	Quartile	All	0.776	0.538	<.001	72	view →
KICH	DFS	Tertile	II,III,IV	0.378	0.950	<.001	71	view →
ACC	DFS	Quartile	All	0.352	0.822	<.001	38	view →
SKCM	DFS	Quartile	All	0.260	0.180	.009	35	view →
SCLC	DFS	Tertile	II,III,IV	0.549	0.213	.006	30	view →
LGG	OS	Quartile	All	0.430	0.697	<.001	25	view →
ESCA	OS	Median	IV	0.143	0.650	.004	24	view →
UCEC	DFS	Median	All	0.792	0.878	.002	24	view →
GBM	DFS	Median	All	0.424	0.153	<.001	18	view →
READ	OS	Quartile	IV	1.000	0.490	.024	17	view →
KIRC	DFS	Median	II,III,IV	0.860	0.658	.005	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PHIP–LIHC (DFS)

Open the LIHC breakdown →