Across TCGA cell cohorts, PHF2 mutation is significantly associated with the RNA expression of many other genes, with 1,185 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHF2-associated genes across cancer lineages are IZUMO3, C10orf53, and C14orf180. Each is linked with PHF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF2-to-partner and partner-to-PHF2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF2→partner) and Y-score (partner→PHF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IZUMO3 →	+0.054	+4.969	<.001	.003	3	2
LARGE_INTESTINE	C10orf53 →	+0.006	+2.172	.009	.007	3	2
LARGE_INTESTINE	C14orf180 →	+0.078	+1.932	<.001	.008	3	2
LUNG_NSCLC_LUAD	CCDC196 →	+0.060	+3.706	<.001	.005	3	2
BLOOD_Myeloma	KRTAP3-2 →	+0.943	+4.807	.001	.006	3	1
CNS	APOBEC1 →	+0.017	+4.754	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,185 associations by consensus.

Exploration

PHF2 survival (RNA) · tumor vs normal (RNA) · all PHF2 data types