Q-omics provides the consensus-scored PHBP21 profile across patient tissues and cancer cell-line models. PHBP21 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, PHBP21 is differentially expressed in 9, with the highest sampling consensus in LIHC. Additionally, PHBP21 RNA expression shows 8,747 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight UVM, LIHC, and GBM as cancer lineages where PHBP21 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PHBP21 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PHBP21 survival associations across molecular data types. PHBP21 RNA expression shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PHBP21 RNA expression–survival associations across cancer types. High PHBP21 expression shows unfavorable associations in UVM, KICH, LIHC, LGG and BRCA, but favorable associations in COAD. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for PHBP21 RNA expression.
This table summarizes PHBP21 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in LIHC for RNA.
This table ranks reproducible tumor–normal expression differences for PHBP21. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PHBP21 shows higher tumor expression in LIHC, BLCA, COAD, HNSC, LUSC and STAD. The LIHC box plot shows higher PHBP21 RNA expression in tumor versus normal tissue (log2 FC = +0.072, t-test p < 0.001).
This table shows molecular features associated with PHBP21 in patient tissues and cancer cell lines. In patient samples, PHBP21 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set.
