PHBP21

Across TCGA pan-cancer cohorts, PHBP21 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PHBP21’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where PHBP21 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PHBP21 is over-expressed in tumor.

LIHC, BLCA, and COAD are the cancer types where PHBP21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PHBP21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	All	+0.072	<.001	6	view →
BLCA	All	All	+0.128	.002	5	view →
COAD	Female	II,III,IV	+0.538	.008	4	view →
HNSC	Male	IV	+0.190	.010	4	view →
LUSC	Male	All	+0.097	<.001	4	view →
STAD	All	All	+0.175	.012	3	view →
LUAD	Female	All	+0.099	.034	2	view →
THCA	Female	II,III,IV	+0.090	.008	2	view →
CHOL	Male	All	+0.133	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

PHBP21–LIHC

Open the LIHC breakdown →