PGR

Across TCGA cell cohorts, PGR mutation is significantly associated with the RNA expression of many other genes, with 685 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PGR-associated genes across cancer lineages are OR8B12, PMPCB, and BCAS2. Each is linked with PGR in more than 1 cancer types. Because this analysis shows association rather than direction, both PGR-to-partner and partner-to-PGR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B12 grouped by PGR-low versus PGR-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGR→partner) and Y-score (partner→PGR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR8B12 →	+0.039	+3.149	<.001	.002	3	2
LARGE_INTESTINE	PMPCB →	+0.351	+3.169	.006	.009	3	2
LARGE_INTESTINE	BCAS2 →	+0.517	+2.502	.002	.005	3	2
BLOOD_Leukemia	TMEM131L →	+1.204	+2.489	<.001	.007	3	2
LARGE_INTESTINE	EPS8L1 →	-1.212	-3.169	.004	.009	3	2
LARGE_INTESTINE	GAL3ST2 →	+1.339	+2.502	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 685 associations by consensus.

OR8B12 by PGR expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →