PGR

Across TCGA pan-cancer cohorts, PGR RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PGR’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PGR RNA is repressed in tumor relative to normal tissue. In most cancer types PGR is over-expressed in tumor, although a few such as BLCA and LUAD show the opposite, repressed pattern.

BLCA, LUAD, and COAD are the cancer types where PGR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PGR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	−1.662	<.001	12	view →
LUAD	Female	III,IV	−1.078	<.001	11	view →
COAD	Male	II,III,IV	−0.793	<.001	11	view →
LUSC	Female	II,III,IV	−1.327	<.001	9	view →
KIRC	Male	All	−0.537	<.001	9	view →
KICH	All	II,III,IV	+1.038	.002	7	view →
KIRP	Male	All	−0.778	<.001	7	view →
STAD	All	All	−0.906	<.001	6	view →
UCEC	All	All	−1.977	<.001	4	view →
READ	All	All	−1.311	.001	3	view →
THCA	All	III,IV	+0.458	.015	3	view →
PRAD	All	All	−0.773	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PGR–BLCA

Open the BLCA breakdown →