PGBD5

Across TCGA patient cohorts, PGBD5 mutation is significantly associated with the RNA expression of many other genes, with 3,488 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGBD5-associated genes across cancer lineages are MRPS35, GSKIP, and GSR. Each is linked with PGBD5 in more than 2 cancer types. Because this analysis shows association rather than direction, both PGBD5-to-partner and partner-to-PGBD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS35 grouped by PGBD5-low versus PGBD5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGBD5→partner) and Y-score (partner→PGBD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPS35 →	+0.310	+1.732	.005	.001	3	3
UCEC	GSKIP →	+0.428	+1.901	<.001	<.001	3	3
UCEC	GSR →	+0.507	+2.269	<.001	<.001	3	3
UCEC	GRPEL1 →	+0.394	+2.321	<.001	<.001	3	3
UCEC	RARS1 →	+0.309	+1.595	<.001	<.001	3	3
UCEC	EIF4E2 →	+0.180	+1.450	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,488 associations by consensus.

MRPS35 by PGBD5 expression — UCEC

Explore this box plot interactively →