PGBD5

Across TCGA pan-cancer cohorts, PGBD5 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PGBD5 data layer compared with 6 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher PGBD5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PGBD5 expression acts as an unfavorable survival marker, although some lineages such as PAAD and KIRC show a favorable association.

THCA, KIRP, and BRCA are the cancer types where PGBD5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Median	All	0.759	0.885	<.001	62	view →
KIRP	DFS	Tertile	All	0.591	0.913	.005	56	view →
BRCA	DFS	Quartile	All	0.869	0.939	<.001	50	view →
ACC	DFS	Median	II,III,IV	0.173	0.611	<.001	44	view →
UVM	DFS	Tertile	III,IV	0.161	0.870	.001	41	view →
PAAD	DFS	Median	All	0.396	0.178	.002	24	view →
KIRC	DFS	Quartile	All	0.908	0.818	.011	22	view →
GBM	OS	Quartile	All	0.299	0.508	.002	19	view →
UCS	OS	Tertile	IV	0.756	0.416	.024	18	view →
LUAD	DFS	Tertile	All	0.230	0.441	.003	18	view →
SKCM	DFS	Quartile	II,III,IV	0.625	0.489	.014	17	view →
DLBC	OS	Quartile	All	1.000	0.363	.018	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PGBD5–THCA (DFS)

Open the THCA breakdown →