PGBD5

Across TCGA pan-cancer cohorts, PGBD5 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PGBD5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where PGBD5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PGBD5 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KIRP, KIRC, and HNSC are the cancer types where PGBD5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PGBD5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	+1.863	<.001	11	view →
KIRC	Female	III,IV	+1.690	<.001	11	view →
HNSC	All	III,IV	+1.013	<.001	9	view →
LIHC	Male	All	+0.811	<.001	7	view →
KICH	All	All	−0.643	.001	6	view →
LUSC	Male	All	+1.134	<.001	4	view →
UCEC	All	All	−0.989	.001	4	view →
STAD	All	All	+0.491	.003	4	view →
COAD	Male	All	−0.380	.001	4	view →
BRCA	Female	All	+0.332	.002	4	view →
LUAD	All	All	+0.424	.011	3	view →
CHOL	All	All	+1.836	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PGBD5–KIRP

Open the KIRP breakdown →