PGBD5

Across TCGA cell cohorts, PGBD5 mutation is significantly associated with the RNA expression of many other genes, with 319 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PGBD5-associated genes across cancer lineages are PHOX2B, HHLA1, and INSM2. Each is linked with PGBD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGBD5-to-partner and partner-to-PGBD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHOX2B grouped by PGBD5-low versus PGBD5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGBD5→partner) and Y-score (partner→PGBD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PHOX2B →	+0.018	+4.365	<.001	.002	3	1
BLOOD_Leukemia	HHLA1 →	+0.011	+4.966	<.001	<.001	3	1
BLOOD_Leukemia	INSM2 →	+0.153	+3.769	.004	.008	3	1
BLOOD_Leukemia	RXFP3 →	+0.010	+3.874	<.001	.005	3	1
BLOOD_Leukemia	CCT8L2 →	+0.009	+3.874	<.001	.005	3	1
BLOOD_Leukemia	TSSK1B →	+0.015	+3.874	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 319 associations by consensus.

PHOX2B by PGBD5 expression — BLOOD_Leukemia

Explore this box plot interactively →