PGAP6

Across TCGA cell cohorts, PGAP6 mutation is significantly associated with the RNA expression of many other genes, with 60 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PGAP6-associated genes across cancer lineages are PROKR1, FAM205A, and IL17F. Each is linked with PGAP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGAP6-to-partner and partner-to-PGAP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROKR1 grouped by PGAP6-low versus PGAP6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAP6→partner) and Y-score (partner→PGAP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PROKR1 →	+0.042	+3.648	.001	.002	3	2
LARGE_INTESTINE	FAM205A →	+0.015	+4.252	.002	<.001	3	2
URINARY_TRACT	IL17F →	+0.042	+4.087	<.001	.009	3	1
URINARY_TRACT	TARM1 →	+0.020	+4.087	<.001	.009	3	1
OVARY	ASB17 →	+0.011	+3.807	<.001	.009	3	1
OVARY	OR2C1 →	+0.060	+3.959	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

PROKR1 by PGAP6 expression — LARGE_INTESTINE

Explore this box plot interactively →