PGAP6

Across TCGA pan-cancer cohorts, PGAP6 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PGAP6 data layer compared with 2 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PGAP6 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PGAP6 expression acts as an unfavorable survival marker, although some lineages such as LUAD and STAD show a favorable association.

ACC, KIRC, and UVM are the cancer types where PGAP6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.731	0.981	<.001	75	view →
KIRC	DFS	Quartile	III,IV	0.632	0.828	.003	60	view →
UVM	DFS	Quartile	All	0.461	0.940	.001	57	view →
LGG	DFS	Median	All	0.310	0.491	<.001	54	view →
LUSC	DFS	Quartile	All	0.310	0.499	.001	49	view →
BLCA	DFS	Median	III,IV	0.219	0.487	.001	37	view →
LUAD	OS	Quartile	II,III,IV	0.840	0.610	.002	34	view →
READ	OS	Median	IV	0.706	1.000	.007	32	view →
LIHC	OS	Median	All	0.423	0.584	.001	30	view →
STAD	OS	Tertile	All	0.740	0.564	.005	26	view →
CESC	DFS	Quartile	All	0.628	0.848	.001	26	view →
COAD	OS	Tertile	IV	0.757	0.337	.002	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PGAP6–ACC (OS)

Open the ACC breakdown →