PGAP2

Across TCGA patient cohorts, PGAP2 mutation is significantly associated with the RNA expression of many other genes, with 1,858 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGAP2-associated genes across cancer lineages are MTCO3P10, IGHVIII-38-1, and MIR1266. Each is linked with PGAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGAP2-to-partner and partner-to-PGAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCO3P10 grouped by PGAP2-low versus PGAP2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAP2→partner) and Y-score (partner→PGAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MTCO3P10 →	+0.091	+5.812	.003	.003	3	2
CESC	IGHVIII-38-1 →	+0.647	+5.669	<.001	.003	3	2
UCEC	MIR1266 →	+0.164	+2.964	.007	.002	3	2
UCEC	LINC02854 →	+0.047	+3.260	<.001	.004	3	2
COAD	MIR3181 →	+1.348	+4.754	<.001	.003	3	2
BRCA	MIR8062 →	+0.387	+7.471	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,858 associations by consensus.

MTCO3P10 by PGAP2 expression — CESC

Explore this box plot interactively →