PGAM5

Across TCGA patient cohorts, PGAM5 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,051 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PGAM5-associated proteins across cancer lineages are RRM1, SMC2, and SMC4. Each is linked with PGAM5 in more than 7 cancer types. Because this analysis shows association rather than direction, both PGAM5-to-partner and partner-to-PGAM5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PGAM5 versus RRM1 in UCEC, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAM5→partner) and Y-score (partner→PGAM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RRM1 →	+0.591	+0.772	<.001	<.001	3	8
UCEC	SMC2 →	+0.690	+0.682	<.001	.001	3	8
UCEC	SMC4 →	+0.582	+0.562	<.001	.008	3	8
LSCC	UNG_S23 →	+0.890	+0.422	<.001	<.001	3	8
LUAD	ZWILCH →	+0.523	+0.582	<.001	<.001	3	8
LSCC	NAA25 →	+0.359	+0.742	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,051 associations by consensus.

PGAM5 vs RRM1 — UCEC

Explore this scatter interactively →