PGAM5

Across TCGA pan-cancer cohorts, PGAM5 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of PGAM5’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PGAM5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PGAM5 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

BLCA, COAD, and LUAD are the cancer types where PGAM5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PGAM5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+1.389	<.001	12	view →
COAD	Female	III,IV	+1.570	<.001	11	view →
LUAD	All	III,IV	+1.010	<.001	11	view →
HNSC	Male	All	+0.918	<.001	11	view →
KIRP	All	II,III,IV	+0.876	<.001	11	view →
LIHC	Male	III,IV	+1.020	<.001	9	view →
LUSC	Male	III,IV	+1.885	<.001	8	view →
STAD	Male	II,III,IV	+1.343	<.001	8	view →
UCEC	All	III,IV	+1.395	<.001	6	view →
BRCA	All	III,IV	+0.816	<.001	6	view →
CHOL	Male	All	+1.435	<.001	4	view →
KIRC	Male	All	−0.253	.004	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

PGAM5–BLCA

Open the BLCA breakdown →