PGAM5

Across TCGA patient cohorts, PGAM5 mutation is significantly associated with the RNA expression of many other genes, with 805 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGAM5-associated genes across cancer lineages are IGHD5-12, TRIM53CP, and CDRT15P8. Each is linked with PGAM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGAM5-to-partner and partner-to-PGAM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD5-12 grouped by PGAM5-low versus PGAM5-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAM5→partner) and Y-score (partner→PGAM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	IGHD5-12 →	+1.494	+5.421	<.001	.005	3	2
UCEC	TRIM53CP →	+0.374	+2.483	.009	.001	3	2
READ	CDRT15P8 →	+0.101	+5.421	<.001	.005	3	1
UCEC	NOCT →	+0.653	+3.467	.003	.002	3	1
UCEC	KCTD14 →	+0.917	+2.617	.008	.006	3	1
UCEC	VPS26B →	+0.467	+2.606	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 805 associations by consensus.

IGHD5-12 by PGAM5 expression — READ

Explore this box plot interactively →