PFKM

Across TCGA patient cohorts, PFKM protein abundance is significantly associated with the RNA expression of many other genes, with 11,658 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PFKM-associated genes across cancer lineages are SYNPO2, CCDC184, and PWWP3B. Each is linked with PFKM in more than 5 cancer types. Because this analysis shows association rather than direction, both PFKM-to-partner and partner-to-PFKM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PFKM versus SYNPO2 in UCEC, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKM→partner) and Y-score (partner→PFKM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SYNPO2 →	+1.475	+0.664	<.001	<.001	3	6
LSCC	CCDC184 →	+0.705	+0.360	<.001	<.001	3	6
BRCA	PWWP3B →	+1.029	+0.447	<.001	<.001	3	5
BRCA	ARHGEF25 →	+0.672	+0.511	<.001	<.001	3	5
BRCA	NFATC4 →	+0.878	+0.417	.001	.001	3	4
COAD	BEX4 →	+0.943	+0.254	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,658 associations by consensus.

PFKM vs SYNPO2 — UCEC

Explore this scatter interactively →