PFKM

Across TCGA pan-cancer cohorts, PFKM RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PFKM data layer compared with 11 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PFKM RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PFKM expression acts as an unfavorable survival marker, although some lineages such as LGG and KIRC show a favorable association.

HNSC, BLCA, and UVM are the cancer types where PFKM RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.451	0.716	<.001	92	view →
BLCA	OS	Median	II,III,IV	0.348	0.501	.007	56	view →
UVM	DFS	Quartile	All	0.260	0.747	.002	43	view →
LGG	DFS	Median	All	0.813	0.657	<.001	39	view →
KIRC	OS	Median	All	0.727	0.557	<.001	38	view →
COAD	DFS	Quartile	IV	0.254	0.565	.005	34	view →
UCEC	DFS	Quartile	All	0.568	0.741	<.001	28	view →
CESC	OS	Median	All	0.841	0.904	.010	28	view →
LIHC	DFS	Median	All	0.234	0.337	.005	22	view →
LUAD	DFS	Tertile	IV	0.290	0.788	.002	19	view →
PAAD	OS	Quartile	All	0.548	0.220	.006	12	view →
BRCA	OS	Tertile	III,IV	0.932	0.845	.018	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PFKM–HNSC (OS)

Open the HNSC breakdown →