PFKM

Across TCGA patient cohorts, PFKM mutation is significantly associated with the RNA expression of many other genes, with 2,585 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PFKM-associated genes across cancer lineages are SPINT5P, MIR8066, and THRAP3P2. Each is linked with PFKM in more than 2 cancer types. Because this analysis shows association rather than direction, both PFKM-to-partner and partner-to-PFKM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINT5P grouped by PFKM-low versus PFKM-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKM→partner) and Y-score (partner→PFKM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SPINT5P →	+0.224	+4.989	<.001	<.001	3	3
BRCA	MIR8066 →	+0.715	+4.390	<.001	<.001	3	2
BRCA	THRAP3P2 →	+0.070	+3.441	.001	.009	3	2
HNSC	NPVF →	+0.054	+5.015	.001	.009	3	2
SKCM	HMGB3P3 →	+0.105	+4.292	<.001	.001	3	2
SKCM	RN7SL163P →	+0.168	+3.408	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,585 associations by consensus.

SPINT5P by PFKM expression — LUSC

Explore this box plot interactively →