PFKL

Across TCGA patient cohorts, PFKL mutation is significantly associated with the RNA expression of many other genes, with 2,788 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PFKL-associated genes across cancer lineages are EI24, TPPP3, and NUDT2. Each is linked with PFKL in more than 2 cancer types. Because this analysis shows association rather than direction, both PFKL-to-partner and partner-to-PFKL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EI24 grouped by PFKL-low versus PFKL-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKL→partner) and Y-score (partner→PFKL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EI24 →	+0.423	+3.459	.004	.005	3	3
UCEC	TPPP3 →	-1.293	-1.584	.003	.005	3	3
UCEC	NUDT2 →	+0.591	+2.432	<.001	<.001	3	3
COAD	FXN →	+0.586	+3.486	<.001	.002	3	3
UCEC	BTBD6 →	+0.349	+2.408	<.001	<.001	3	3
UCEC	HEXIM1 →	+0.521	+3.021	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,788 associations by consensus.

EI24 by PFKL expression — COAD

Explore this box plot interactively →