PFKL

Across TCGA pan-cancer cohorts, PFKL RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PFKL data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher PFKL RNA is associated with better overall survival. In most high-consensus cancer types, elevated PFKL expression acts as an unfavorable survival marker, although some lineages such as SCLC and DLBC show a favorable association.

SCLC, BRCA, and LGG are the cancer types where PFKL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Tertile	All	0.884	0.506	<.001	61	view →
BRCA	DFS	Quartile	All	0.853	0.925	.002	59	view →
LGG	OS	Median	All	0.359	0.526	<.001	40	view →
MESO	OS	Quartile	III,IV	0.363	0.698	.005	38	view →
DLBC	DFS	Tertile	All	1.000	0.366	.004	38	view →
LAML	DFS	Tertile	All	0.264	0.517	<.001	36	view →
KIRP	DFS	Median	IV	0.039	0.526	.027	22	view →
HNSC	OS	Quartile	All	0.236	0.565	.005	22	view →
SARC	OS	Median	All	0.384	0.614	<.001	21	view →
COAD	OS	Quartile	All	0.807	0.951	.017	16	view →
ACC	DFS	Quartile	All	0.425	0.773	.010	16	view →
OV	OS	Tertile	All	0.282	0.399	.003	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PFKL–SCLC (OS)

Open the SCLC breakdown →