PFKL

Across TCGA pan-cancer cohorts, PFKL RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PFKL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PFKL RNA is repressed in tumor relative to normal tissue. In most cancer types PFKL is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, HNSC, and KIRC are the cancer types where PFKL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PFKL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.486	<.001	10	view →
HNSC	Male	III,IV	+0.747	<.001	10	view →
KIRC	Female	IV	+1.030	<.001	8	view →
LIHC	Female	II,III,IV	+1.041	<.001	7	view →
LUSC	Female	All	+0.822	<.001	6	view →
UCEC	All	III,IV	+0.790	<.001	6	view →
KIRP	Male	All	−0.667	<.001	6	view →
LUAD	Female	II,III,IV	+0.420	.007	6	view →
STAD	Male	II,III,IV	+0.698	.007	4	view →
BRCA	All	All	+0.276	.003	4	view →
CHOL	Male	All	+0.936	<.001	2	view →
BLCA	All	All	+0.505	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PFKL–KICH

Open the KICH breakdown →