PFKL

Across TCGA patient cohorts, PFKL mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PFKL-associated genes across cancer lineages are eIF4E, FoxM1, and MSH2. Each is linked with PFKL in more than 1 cancer types. Because this analysis shows association rather than direction, both PFKL-to-partner and partner-to-PFKL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PFKL-low versus PFKL-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKL→partner) and Y-score (partner→PFKL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.265	+2.820	.001	.035	3	2
UCEC	FoxM1 →	+0.200	+1.736	.026	.007	3	2
UCEC	MSH2 →	-0.164	-2.295	.040	.033	3	2
UCEC	PCNA →	+0.231	+3.000	.002	<.001	3	2
UCEC	ATM →	-0.385	-1.440	.014	.024	3	2
COAD	p38-MAPK →	+0.201	+3.169	.014	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

eIF4E by PFKL expression — COAD

Explore this box plot interactively →