PFKL

Across TCGA cell cohorts, PFKL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,432 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PFKL-associated GO terms across cancer lineages are Positive regulation of intracellular steroid hormone receptor signaling pathway, Glucose catabolic process, and Regulation of anaphase-promoting complex-dependent catabolic process. Each is linked with PFKL in more than 12 cancer types. Because this analysis shows association rather than direction, both PFKL-to-partner and partner-to-PFKL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular steroid hormone receptor signaling pathway grouped by PFKL-low versus PFKL-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKL→partner) and Y-score (partner→PFKL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.136	+1.140	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Glucose catabolic process →	+0.140	+1.178	<.001	<.001	3	12
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.143	+0.870	.001	<.001	3	12
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.134	+0.672	.004	.003	3	12
UPPER_AERODIGESTIVE_TRACT	Glucose metabolic process →	+0.079	+0.970	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Canonical glycolysis →	+0.123	+1.243	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,432 associations by consensus.

Positive regulation of intracellular steroid hormone receptor signaling pathway by PFKL expression — OVARY

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