PFKL

Across TCGA cell cohorts, PFKL mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PFKL-associated genes across cancer lineages are OR4X2, KRTAP1-1, and RPL10L. Each is linked with PFKL in more than 1 cancer types. Because this analysis shows association rather than direction, both PFKL-to-partner and partner-to-PFKL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4X2 grouped by PFKL-low versus PFKL-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKL→partner) and Y-score (partner→PFKL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR4X2 →	+0.018	+5.369	.001	.004	3	2
BLOOD_Lymphoma	KRTAP1-1 →	+0.068	+5.209	<.001	.005	3	2
SOFT_TISSUE	RPL10L →	+0.038	+4.930	<.001	.008	3	1
SOFT_TISSUE	PGK2 →	+0.209	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR52J3 →	+0.026	+5.369	<.001	.004	3	1
SOFT_TISSUE	MROH5 →	+0.021	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

OR4X2 by PFKL expression — SOFT_TISSUE

Explore this box plot interactively →