PFDN4

Across TCGA patient cohorts, PFDN4 mutation is significantly associated with the RNA expression of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PFDN4-associated genes across cancer lineages are SMIM7P1, WDR45BP1, and ATP6V1E1P2. Each is linked with PFDN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PFDN4-to-partner and partner-to-PFDN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM7P1 grouped by PFDN4-low versus PFDN4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFDN4→partner) and Y-score (partner→PFDN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SMIM7P1 →	+0.282	+5.283	.003	.006	3	2
UCEC	WDR45BP1 →	+0.546	+3.225	<.001	.009	3	1
UCEC	ATP6V1E1P2 →	+0.295	+3.077	<.001	.001	3	1
UCEC	FOXJ2 →	+0.584	+3.223	.007	.009	3	1
UCEC	AP4E1 →	+0.608	+3.234	.001	.009	3	1
UCEC	MIR6750 →	+0.694	+2.561	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

SMIM7P1 by PFDN4 expression — COAD

Explore this box plot interactively →