PEX5L

Across TCGA cell cohorts, PEX5L mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PEX5L-associated genes across cancer lineages are MYL2, AICDA, and PSG8. Each is linked with PEX5L in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX5L-to-partner and partner-to-PEX5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYL2 grouped by PEX5L-low versus PEX5L-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX5L→partner) and Y-score (partner→PEX5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MYL2 →	+0.262	+4.684	<.001	<.001	3	1
LUNG_SCLC	AICDA →	+0.047	+3.898	.009	.005	3	1
LUNG_SCLC	PSG8 →	+0.098	+3.898	<.001	.005	3	1
LUNG_SCLC	IL36A →	+0.016	+4.058	<.001	.007	3	1
LUNG_SCLC	DIPK2B →	+0.015	+3.736	<.001	.007	3	1
LUNG_SCLC	LCE3D →	+0.068	+3.817	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

MYL2 by PEX5L expression — LUNG_SCLC

Explore this box plot interactively →