PEX5

Across TCGA patient cohorts, PEX5 mutation is significantly associated with the RNA expression of many other genes, with 2,059 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEX5-associated genes across cancer lineages are TTTY2, PGAP2, and TKFC. Each is linked with PEX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX5-to-partner and partner-to-PEX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTTY2 grouped by PEX5-low versus PEX5-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX5→partner) and Y-score (partner→PEX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TTTY2 →	+0.014	+7.954	<.001	.008	3	2
UCEC	PGAP2 →	+0.431	+2.069	<.001	<.001	3	2
UCEC	TKFC →	+0.372	+2.024	.001	.005	3	2
UCEC	EI24 →	+0.477	+2.378	<.001	<.001	3	2
UCEC	ICOS →	+0.402	+2.080	.002	<.001	3	2
UCEC	NPR1 →	-0.830	-2.048	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,059 associations by consensus.

TTTY2 by PEX5 expression — HNSC

Explore this box plot interactively →