PEX5

Across TCGA pan-cancer cohorts, PEX5 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PEX5 data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher PEX5 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PEX5 expression acts as an unfavorable survival marker, although some lineages such as STAD and KIRC show a favorable association.

STAD, KIRC, and COAD are the cancer types where PEX5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Quartile	III,IV	0.668	0.368	<.001	65	view →
KIRC	DFS	Median	All	0.706	0.543	<.001	49	view →
COAD	DFS	Median	III,IV	0.323	0.536	.003	49	view →
READ	DFS	Median	IV	0.776	0.368	.006	41	view →
ACC	DFS	Quartile	All	0.325	0.758	.002	40	view →
CESC	DFS	Quartile	III,IV	0.591	0.937	.015	36	view →
LGG	OS	Median	All	0.936	0.849	<.001	34	view →
KICH	OS	Tertile	II,III,IV	0.605	0.932	.034	24	view →
OV	OS	Median	All	0.816	0.863	.034	16	view →
THYM	OS	Tertile	All	1.000	0.790	.015	14	view →
PAAD	OS	Quartile	All	0.562	0.166	.005	8	view →
THCA	OS	Median	II,III,IV	0.932	1.000	.017	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PEX5–STAD (OS)

Open the STAD breakdown →