PEX5

Across TCGA pan-cancer cohorts, PEX5 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PEX5’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PEX5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PEX5 is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

COAD, LIHC, and LUAD are the cancer types where PEX5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PEX5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+0.894	<.001	10	view →
LIHC	Male	All	+0.715	<.001	8	view →
LUAD	Female	All	−0.551	<.001	8	view →
HNSC	All	All	+0.453	<.001	8	view →
KIRC	All	III,IV	+0.304	.001	8	view →
THCA	Male	All	−0.433	<.001	7	view →
BRCA	Female	All	−0.301	<.001	6	view →
STAD	All	II,III,IV	+0.649	.001	4	view →
LUSC	Male	All	+0.373	<.001	4	view →
CHOL	Female	All	+1.349	<.001	3	view →
ESCA	Female	All	+0.860	.001	2	view →
KICH	All	All	−0.504	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PEX5–COAD

Open the COAD breakdown →