PEX5

Across TCGA patient cohorts, PEX5 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEX5-associated genes across cancer lineages are eIF4G, Rictor_pT1135, and Caspase-8. Each is linked with PEX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX5-to-partner and partner-to-PEX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by PEX5-low versus PEX5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX5→partner) and Y-score (partner→PEX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.268	+2.459	.011	.018	3	2
UCEC	Rictor_pT1135 →	-0.101	-2.502	.003	.001	3	2
UCEC	Caspase-8 →	-0.204	-3.780	.017	<.001	3	2
UCEC	EGFR_pY1068 →	-0.190	-1.700	.026	.040	3	1
UCEC	EGFR →	-0.133	-2.295	.014	.033	3	1
UCEC	A-Raf_pS299 →	-0.121	-2.000	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

eIF4G by PEX5 expression — UCEC

Explore this box plot interactively →