PEX5

Across TCGA cell cohorts, PEX5 mutation is significantly associated with the RNA expression of many other genes, with 720 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PEX5-associated genes across cancer lineages are OR2W5, MS4A10, and CRYGC. Each is linked with PEX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX5-to-partner and partner-to-PEX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2W5 grouped by PEX5-low versus PEX5-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX5→partner) and Y-score (partner→PEX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	OR2W5 →	+0.030	+4.807	<.001	.006	3	1
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1
BLOOD_Leukemia	CRYGC →	+0.020	+4.384	<.001	.006	3	1
BLOOD_Leukemia	RGS7 →	+0.327	+3.769	<.001	.008	3	1
BLOOD_Leukemia	GSG1L2 →	+0.034	+4.384	<.001	.006	3	1
LARGE_INTESTINE	MIOX →	+0.397	+3.087	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 720 associations by consensus.

OR2W5 by PEX5 expression — BLOOD_Myeloma

Explore this box plot interactively →