PEX12

Across TCGA patient cohorts, PEX12 mutation is significantly associated with the RNA expression of many other genes, with 3,155 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEX12-associated genes across cancer lineages are HMGN2P32, HMGN2P24, and MRPS36P1. Each is linked with PEX12 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX12-to-partner and partner-to-PEX12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGN2P32 grouped by PEX12-low versus PEX12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX12→partner) and Y-score (partner→PEX12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMGN2P32 →	+0.494	+2.475	<.001	<.001	3	2
UCEC	HMGN2P24 →	+0.230	+1.746	.006	.006	3	2
UCEC	MRPS36P1 →	+0.486	+2.914	<.001	<.001	3	2
LUSC	RN7SL97P →	+0.228	+4.984	<.001	.009	3	2
CESC	RN7SL66P →	+0.177	+4.010	<.001	.002	3	2
CESC	VN1R90P →	+0.050	+3.542	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,155 associations by consensus.

HMGN2P32 by PEX12 expression — UCEC

Explore this box plot interactively →