PENK

Across TCGA patient cohorts, PENK RNA expression is significantly associated with the protein abundance of many other proteins, with 9,192 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PENK-associated proteins across cancer lineages are TLN2, CAVIN1, and CAVIN3. Each is linked with PENK in more than 5 cancer types. Because this analysis shows association rather than direction, both PENK-to-partner and partner-to-PENK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PENK versus TLN2 in BRCA, with a Pearson correlation of 0.42.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PENK→partner) and Y-score (partner→PENK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TLN2 →	+0.487	+0.366	<.001	<.001	3	6
BRCA	CAVIN1 →	+0.922	+0.662	<.001	<.001	3	5
BRCA	CAVIN3 →	+0.940	+0.621	<.001	<.001	3	5
OV	CD248 →	+0.612	+0.313	<.001	<.001	3	5
BRCA	CDH13 →	+0.561	+0.454	.001	<.001	3	5
BRCA	CNRIP1 →	+0.582	+0.362	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,192 associations by consensus.

PENK vs TLN2 — BRCA

Explore this scatter interactively →