PENK

Across TCGA pan-cancer cohorts, PENK RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PENK’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PENK RNA is repressed in tumor relative to normal tissue. In most cancer types PENK is over-expressed in tumor, although a few such as LUAD and BRCA show the opposite, repressed pattern.

LUAD, BRCA, and UCEC are the cancer types where PENK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PENK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	−1.304	<.001	8	view →
BRCA	All	II,III,IV	−1.891	<.001	6	view →
UCEC	All	All	−1.241	.005	6	view →
BLCA	Male	IV	−1.015	.008	6	view →
HNSC	Male	All	−0.668	.001	6	view →
KIRP	All	All	−0.081	.007	6	view →
STAD	All	All	−1.521	.001	5	view →
READ	All	All	−1.954	.003	4	view →
COAD	Male	II,III,IV	−1.434	<.001	4	view →
PRAD	All	All	−1.840	<.001	2	view →
LUSC	All	III,IV	−1.776	<.001	2	view →
KICH	All	All	−0.163	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PENK–LUAD

Open the LUAD breakdown →