PENK

Across TCGA pan-cancer cohorts, PENK RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PENK data layer compared with 5 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher PENK RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PENK expression acts as an unfavorable survival marker, although some lineages such as UCS and HNSC show a favorable association.

UCS, HNSC, and UVM are the cancer types where PENK RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	II,III,IV	0.629	0.132	.001	70	view →
HNSC	DFS	Quartile	All	0.796	0.644	<.001	65	view →
UVM	OS	Quartile	All	0.573	0.844	.001	50	view →
BLCA	OS	Median	All	0.344	0.506	.004	34	view →
KICH	OS	Median	III,IV	1.000	0.494	.008	34	view →
LUAD	DFS	Median	All	0.833	0.696	.001	33	view →
UCEC	DFS	Median	All	0.550	0.721	.005	30	view →
CHOL	DFS	Tertile	II,III,IV	0.696	0.134	.026	24	view →
LAML	DFS	Quartile	All	0.311	0.667	<.001	18	view →
DLBC	OS	Median	II,III,IV	0.827	1.000	.016	14	view →
KIRP	DFS	Median	All	0.612	0.856	.016	13	view →
ESCA	OS	Median	IV	0.222	0.698	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PENK–UCS (DFS)

Open the UCS breakdown →