PENK

Across TCGA patient cohorts, PENK mutation is significantly associated with the RNA expression of many other genes, with 2,475 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PENK-associated genes across cancer lineages are RBAK-RBAKDN, TOE1, and OFD1P5Y. Each is linked with PENK in more than 2 cancer types. Because this analysis shows association rather than direction, both PENK-to-partner and partner-to-PENK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBAK-RBAKDN grouped by PENK-low versus PENK-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PENK→partner) and Y-score (partner→PENK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RBAK-RBAKDN →	+0.122	+1.702	<.001	<.001	3	3
SKCM	TOE1 →	+0.264	+1.479	.002	.001	3	3
BLCA	OFD1P5Y →	+0.011	+5.399	<.001	<.001	3	3
UCEC	HAUS8 →	+0.560	+3.321	<.001	<.001	3	3
UCEC	HAUS2 →	+0.601	+2.711	<.001	.003	3	3
UCEC	CCDC150 →	+0.443	+3.483	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,475 associations by consensus.

RBAK-RBAKDN by PENK expression — SKCM

Explore this box plot interactively →