PENK

Across TCGA patient cohorts, PENK mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PENK-associated genes across cancer lineages are ASNS, FoxM1, and 4E-BP1. Each is linked with PENK in more than 2 cancer types. Because this analysis shows association rather than direction, both PENK-to-partner and partner-to-PENK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PENK-low versus PENK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PENK→partner) and Y-score (partner→PENK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.516	+2.321	<.001	.033	3	3
UCEC	FoxM1 →	+0.245	+1.807	.021	.027	3	2
UCEC	4E-BP1 →	+0.240	+2.351	.032	.018	3	2
UCEC	EGFR_pY1068 →	-0.234	-1.807	.024	.027	3	1
UCEC	eIF4E →	+0.189	+2.321	.030	.006	3	1
UCEC	ACVRL1 →	-0.139	-2.308	.013	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ASNS by PENK expression — UCEC

Explore this box plot interactively →