PENK

Across TCGA cell cohorts, PENK RNA expression is significantly associated with the go_rna of many other GO terms, with 1,557 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PENK-associated GO terms across cancer lineages are Taxis, Chemotaxis, and Regulation of translational initiation. Each is linked with PENK in more than 7 cancer types. Because this analysis shows association rather than direction, both PENK-to-partner and partner-to-PENK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Taxis grouped by PENK-low versus PENK-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PENK→partner) and Y-score (partner→PENK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Taxis →	-0.044	-0.082	<.001	<.001	2	8
BLOOD_Lymphoma	Chemotaxis →	-0.044	-0.082	<.001	<.001	2	8
OESOPHAGUS	Regulation of translational initiation →	+0.089	+0.242	.002	.006	2	7
OESOPHAGUS	Cell fate commitment →	-0.055	-0.220	<.001	.004	3	5
BLOOD_Lymphoma	Cell chemotaxis →	-0.056	-0.058	.005	.009	3	5
BREAST	Positive regulation of neurotransmitter transport →	-0.102	-0.165	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,557 associations by consensus.

Taxis by PENK expression — BLOOD_Lymphoma

Explore this box plot interactively →